Electron Microscopy Data Bank

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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sample_name:"Human Amylin 1 Receptor in complex with Gs and human calcitonin gene-related peptide"

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EMD-43877

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Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide

Release date: April 24, 2024
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9auc
Q-score: 0.503

Cao J, Belousoff MJ, Danev R, Christopoulos A, Wootten D, Sexton PM

Biochemistry (2024) [ DOI: doi:10.1021/acs.biochem.4c00114 Pubmed: 38603770 ]

Sample:

Human amylin 1 receptor in complex with gs and human calcitonin gene-related peptide (Complex from Homo sapiens)
Receptor activity-modifying protein 1 (17 kDa, Protein from Homo sapiens)
Cholesterol hemisuccinate (486 Da, Ligand)
Calcitonin gene-related peptide 1 (3 kDa, Protein from Homo sapiens)
Palmitic acid (256 Da, Ligand)
Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Calcitonin receptor (58 kDa, Protein from Homo sapiens)
Water (18 Da, Ligand)
Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Nanobody 35 (15 kDa, Protein from Lama glama)
Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)

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